As part of an ongoing restructuring strategy, CVS Health is set to close 270 more CVS Pharmacy locations across the U.S. in 2025, marking another major step in its multi-year realignment plan. The move comes as the company works to modernize its retail footprint and adapt to evolving consumer behavior and healthcare needs.
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Why Is CVS Closing Hundreds of Pharmacy Stores in 2025?
In its 2025 annual report, CVS confirmed plans to shut down 271 retail locations nationwide. This follows the closure of nearly 900 stores between 2022 and 2024, bringing the total number of planned closures to over 1,100 within a four-year span.
CVS Says Closures Will Streamline Operations
A CVS spokesperson explained the decision stems from a desire to streamline operations and focus on delivering healthcare services more effectively. According to the company, factors such as population shifts, consumer buying habits, pharmacy access, and community health needs all influenced the decision to close select stores.
Importantly, CVS has emphasized that these closures are not a response to industry pressure, but a proactive move to better align store locations with consumer demand and operational efficiency.
CVS Pharmacy Closures in 2025: What Locations Are Impacted?
While CVS has not officially released a comprehensive list of all 270 locations slated for closure, local news reports and consumer watchdogs like The Krazy Coupon Lady have confirmed dozens of store closings, including in key metro areas across California, New York, Florida, and more.
CVS Pharmacy Closings in California 2025
If you’re searching for the list of CVS stores closing in 2025 in California, here are the confirmed locations:
- 499 Haight St., San Francisco
- 1701 K St., Sacramento
These closures are part of a larger trend affecting CVS pharmacies nationwide.
Full List of CVS Pharmacy Closures by State in 2025
Here’s a breakdown of confirmed CVS locations closing in 2025 based on regional news outlets and corporate reports:
Alabama
- 2901 Morgan Rd., Bessemer
- 3303 Clairmont Ave., Birmingham
Florida
- 3090 S. Monroe St., Tallahassee
- 13300 E. Colonial Dr., Orlando
- 2201 Edgewater Dr., Orlando
Georgia
- 439 Highland Blvd., Atlanta
Illinois
- 8639 S. Cicero Ave., Chicago
- 401 W. Armitage Ave., Chicago
- 2000 Skokie Valley Rd., Highland Park
Iowa
- 2420 Lincoln Way, Ames
- 215 Euclid Ave., Des Moines
Massachusetts
- 55 Summer St., Boston
Michigan
- 28774 Gratiot Ave., Roseville
- 27700 Harper Ave., St. Clair Shores
Missouri
- 2435 Independence Ave., Kansas City
- 9433 Manchester Rd., Saint Louis
- 4531 Troost Ave., Kansas City
New York
- 955 Payne Ave., North Tonawanda
- 153 Central Ave., Albany
- 1026 Madison Ave., Albany
- 1241 Lexington Ave., New York City
- 1654 Richmond Ave., Staten Island
North Carolina
- 201 W. 4th St., Winston-Salem
Ohio
- 10825 Kinsman Rd., Cleveland
Pennsylvania
- 125 E. Main St., Plymouth
Virginia
- 10390 Willard Way, Fairfax
Washington, D.C.
- 1117 10th St. NW
- 1100 4th St. SW
- 400 Massachusetts Ave. NW
- 1515 New York Ave. NE
- 4500 Wisconsin Ave. NW
- 7828 Georgia Ave. NW
Indiana
- 9550 Allisonville Rd., Indianapolis
Maryland
- 1000 S. Charles St., Federal Hill, Baltimore
- 7235 Wisconsin Ave., Bethesda
- 34 N. Cannon Ave., Hagerstown (closing June 26)
Texas
- 3890 Phelan Blvd., Beaumont
CVS Closing 270 Stores Nationwide: Is This the End of Brick-and-Mortar Pharmacies?
Despite the scale of the closures, CVS has assured consumers that 85 percent of Americans will still live within 10 miles of a CVS Pharmacy. The closures are being made strategically, not haphazardly, according to the company.
Expansion Still on the Horizon
In fact, CVS plans to open 30 new pharmacy locations in 2025, with many set inside Target stores—a move signaling a shift toward healthcare integration in larger retail environments.
CVS Faces Legal Hurdles in Arkansas Over Pharmacy Ownership Law
One development that may complicate CVS’s strategy is a new Arkansas law aimed at prohibiting Pharmacy Benefit Managers (PBMs) from owning pharmacies. This legislation, signed by Governor Sarah Huckabee Sanders, could impact CVS’s 23 pharmacy locations in Arkansas, where it acts as both a PBM and a retail pharmacy operator.
CVS has expressed concern that the new regulation could force them to reconsider their presence in the state.
What Should Customers Do Next?
Customers affected by CVS closures will typically receive advance notice, and prescriptions will be transferred to nearby CVS or partner pharmacies automatically. CVS recommends visiting cvs.com/store-locator for the most up-to-date information.
Conclusion: CVS Pharmacy Realignment Reshapes the Future of Retail Healthcare
The CVS Pharmacy closing plan in 2025 reflects a strategic shift toward more efficient, customer-centered operations. While the loss of local stores will be disruptive for some, CVS says the move is intended to modernize its retail experience and better meet the changing healthcare needs of American consumers.
As the list of CVS stores closing in 2025 continues to grow, consumers are encouraged to stay informed about local closures and new store openings as CVS reshapes its nationwide footprint.